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Evaluation of patients with retinitis pigmentosa receiving
electric stimulation, ozonated blood, and ocular surgery in Cuba
from Oxygen and Ozone Therapies

Author: Berson EL; Remulla JF; Rosner B; Sandberg MA;
Weigel-DiFranco C

Address: Berman-Gund Laboratory, Harvard Medical School,
Massachusetts Eye and Ear
Infirmary, Boston, USA.

Source: Arch Ophthalmol, 1996 May, 114:5, 560-3

Abstract:

OBJECTIVE: To evaluate the effect of intervention with electric
stimulation, autotransfused ozonated blood, and ocular surgery,
performed in Cuba, on the course of the common forms of retinitis
pigmentosa.

DESIGN: Ocular evaluations over 6 to 8 months before and after
intervention in Cuba.

SETTING: Evaluations performed at a US clinical research facility.

PATIENTS: Ten adult patients aged 25 to 67 years with retinitis
pigmentosa.

MAIN OUTCOME MEASURES: Visual acuity, visual field area, and
electroretinogram (ERG) amplitude. RESULTS: No significant change
in visual acuity or visual field area was observed on average
between preintervention and postintervention values over a 6- to
8-month interval. Mean 30-Hz cone ERG amplitude declined by 15.5%
between preintervention and postintervention values (P = .006).
When data on change in visual field area from 1 statistically
significant outlier were excluded from the analysis, a significant
decline of 12.9% in mean visual field area was observed (P =
.025).

CONCLUSIONS: These data support the conclusion that the
intervention offered in Cuba provides no benefit to patients with
retinitis pigmentosa as measured by visual acuity, visual field
area, and ERG. The magnitudes of the mean declines observed in ERG
amplitude and visual field area over a 6- to 8-month interval,
relative to those reported in previous studies, raise the
possibility that this intervention may worsen the course of the
disease.


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Date last modified August 1, 2001